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As of October 11, 2026, Illumina Inc. (ILMN) trades at $278.17. CleaRank Financial AI rates it Hold with a fair value of $214.00, 23.1% below the current price. Wall Street's consensus target is $214.00 across 21 analysts. RSI at 66 is in neutral territory, and the price is above its 50-day average of $226.92.
Illumina Inc. (ILMN)
Illumina Inc. NASDAQ
$278.17
13.60 (5.14%)
At close: Oct 9, 4:00 PM EDT
AI Analyst Consensus
59 / 100
Illumina Inc. is currently trading at $278.17, above its 50-day and 200-day moving averages ($226.92 and $166.27), indicating positive short-to-medium term technical momentum. The company's strong historical profitability, with a net profit margin of 18.34% and return on equity of 32.34%, contrasts with recent insider activity and a negative analyst outlook. Wall Street analysts maintain a 'Hold' consensus with a median price target of $214.00, implying a -23.1% downside from the current price. This divergence between current price action and analyst sentiment, coupled with significant insider selling totaling $592.9 million against $1.6 million in purchases, presents a key risk. The company's revenue growth is projected at 6.00% for the current year, with forward EPS estimates showing modest growth.
ILMN Price Analysis
Market Metrics
Open
$268.21
Day Range
$265.25 to $278.59
Prev Close
$264.57
Volume
1.90M
52-Week Range
$88.00 to $309.35
Market Cap
$42.00B
Peer Benchmarking
Valuation vs Sector (Healthcare)
Performance vs XLV
Sector Position Analysis
Trading at a significant premium to sector peers (+59%), suggesting market expectations for superior growth or market position.
ILMN Financial Performance
Revenue vs. Earnings
Annual
Quarterly
Earnings Reality Check
Analysis: In the last 1 quarters, ILMN beat estimates 1 times. The stock rose 1 times the next day. Price tends to react positively to beats.
ILMN Analysis
Company's Health
3/5
12-Month Analyst Target
-23.07% Downside
Median of 21 analysts (12-month)
$214.00
AI Technical Analysis
Illumina Inc.'s trading volume was 35.9% below its average on the latest trading day, suggesting a lack of strong conviction despite positive price action. The stock is trading above its 50-day and 200-day moving averages ($226.92 and $166.27), and its 20-day EMA ($258.87), signaling an uptrend. The RSI is at 66.22, indicating bullish momentum. The chart structure suggests that the moving averages are acting as support. The current price action indicates upward momentum. The RSI status is 'BULLISH', reinforcing the positive technical picture, though the lower volume warrants caution regarding the sustainability of the trend.
ProTips
- Monitor insider transactions closely; the current heavy net selling trend is a significant bearish signal that warrants caution.
- Given the premium valuation and negative analyst sentiment, consider waiting for a clearer fundamental catalyst or a more attractive entry point before initiating a long position.
- The company's strong historical profitability and solid balance sheet offer some resilience, but the current market sentiment and valuation suggest a risk-reward profile that may not be favorable for aggressive buying.
Key Catalysts
Bearish
Significant Insider Selling Pressure
Insiders have sold $592.9 million worth of stock against only $1.6 million in purchases, indicating a strong lack of confidence in the company's near-term prospects.
Source: Insider TransactionsBearish
Negative Analyst Price Target Revision
The median analyst price target for Illumina Inc. stands at $214.00, representing a -23.1% downside from the current stock price, suggesting Wall Street's view is becoming more cautious.
Source: Wall Street AnalystsBearish
Recent Earnings Miss
Illumina missed earnings estimates for the quarter ending June 2026, reporting -$0.02 EPS against an expected $0.04, raising concerns about operational execution.
Source: Earnings ReportBullish
Positive Technical Momentum
The stock is trading above its key moving averages (50-day, 200-day, and 20-day EMA) with a 'BULLISH' RSI status, suggesting upward price momentum.
Source: Technical AnalysisNeutral
Strong Historical Profitability
Illumina maintains strong historical financial performance with a net profit margin of 18.34% and return on equity of 32.34%, providing a fundamental underpinning.
Source: Company FundamentalsMarket Outlook
Illumina Inc.'s outlook is cautious, with a median analyst price target of $214.00 suggesting a potential decline from current levels, despite positive technical indicators. The company's strong historical profitability and strong balance sheet provide a foundation, but significant insider selling and a recent earnings miss temper optimism. The base case scenario anticipates a challenging period as the company navigates these headwinds. Upside potential could emerge if Illumina demonstrates consistent earnings beats and reverses the insider selling trend, potentially re-rating its premium valuation. Conversely, continued operational missteps or a worsening macroeconomic environment could push the stock towards its downside targets.
Key Statistics
| Market Cap | 42.00B |
|---|---|
| P/E Ratio | 50.60 |
| EPS (TTM) | 5.36 |
| Dividend Yield | 0.00% |
| 52 Week High | 309.35 |
| 52 Week Low | 88.00 |
Illumina Inc. exhibits a P/E ratio of 50.60, which is significantly higher than the Healthcare sector median of 31.9, suggesting a premium valuation. Its price-to-sales ratio of 9.11 also exceeds the sector average of 3.7. The company's strong historical profitability is evident in its return on equity of 32.34% and a net profit margin of 18.34%, both considerably outperforming sector medians. Despite strong historical performance, the current valuation appears stretched relative to sector averages and forward growth estimates. While the company has a substantial debt-to-equity ratio of 0.89, which is slightly above the sector median of 0.89, its strong profit margins and equity returns provide some fundamental support. However, the high P/E ratio and the significant insider selling raise concerns about future performance.
Earnings & Growth Analysis
Illumina Inc. reported a significant earnings miss for the quarter ending June 2026, with an actual EPS of -$0.02 against an estimate of $0.04, resulting in a -150% surprise and a -1.84% price change. This follows a strong beat in the quarter ending March 2026, where actual EPS of $1.15 exceeded estimates by 9.52% and drove a 7.13% price increase. The company's earnings trajectory shows inconsistency, with a recent negative surprise following a positive one. While the current year's revenue growth is projected at 6.00%, the mixed earnings performance and the recent miss warrant close monitoring of future guidance and operational execution.
Key Risks
Illumina Inc. faces considerable risk from significant insider selling, with over $592 million in dispositions against only $1.6 million in purchases, signaling a lack of confidence from management. The stock's valuation is also a concern, trading at a P/E ratio of 50.60, well above the sector median, and analysts' median price target of $214.00 implies a -23.1% downside. Also, the recent earnings miss in the June 2026 quarter highlights potential operational headwinds that could impact future performance.
Technical Indicators
| RSI (14) | 66.22 |
|---|---|
| MACD | 15.16 |
| SMA 50 | 226.92 |
| SMA 200 | 166.27 |
RSI
Bullish
SMA Cross
Bullish
Price vs SMA
Bullish
MACD
Bullish
Golden Cross in effect with the 50-day SMA ($226.92) above the 200-day SMA ($166.27), price action is firmly bullish above key moving averages.
Market Correlations
How this stock moves relative to other assets
Based on 1 year of daily price data. Correlations may vary over different time periods.
S&P 500 (SPY)
+0.37
Weak correlation
Nasdaq 100 (QQQ)
+0.34
Weak correlation
Bitcoin (BTC)
+0.28
Weak correlation
Gold (XAU)
+0.06
Weak correlation
Check Custom Correlation
How does any other asset move with ILMN? One year of daily closes, Pearson correlation.
Try
ILMN Trade Plans
Specific entry, exit, and risk management levels
Select Your Trade Bias
Risk Tolerance
Conservative
2%
Aggressive
Portfolio Value
$
Position Size: Enter portfolio size →
Entry Strategies pick an entry style
Conservative
$275.39
Slight discount to current
Wait for small dip
Aggressive
$278.17
At current price
Enter now if confident
Risk Management
STOP LOSS
$254.62
MAX LOSS
-7.5%
Volatility-Adjusted Stop Loss
Calculated based on RSI (66.2) and current market volatility
Profit Targets (Based on Conservative Entry)
TARGET 1
$283.65
+3% (Conservative)
+2.0% (Aggressive)
TARGET 2
$289.16
+5% (Conservative)
+4.0% (Aggressive)
TARGET 3
$297.42
+8% (Conservative)
+6.9% (Aggressive)
Consider scaling out: Take 50% profit at Target 1, 30% at Target 2, let 20% run to Target 3
Calculate Your Trade
High-Volatility Risk Disclaimer
ILMN is classified as a high-volatility asset (Daily Vol: 3.63%). Aggressive price swings can lead to rapid capital loss. Liquidity risks may prevent exiting trades at desired prices. This AI-generated analysis is for educational purposes only and is not financial advice. Generated on October 11, 2026.Growth of $10,000
A $10,000 investment in ILMN in October 2016 would be worth about $20,574 today, compared with about $36,479 for the same investment in the S&P 500 benchmark.
Compare with Another Ticker
Monte Carlo Projection (10yr)
CleaRank's 10-year Monte Carlo simulation projects that a $10,000 investment in ILMN today could grow to about $20,310 by 2036 in the base case, with a bull case near $110,737 and a bear case around $3,725. Projections are statistical simulations, not guarantees.
ILMN Stock Price Prediction: 2030
CleaRank's simulation projects a price near $369 for ILMN by 2030 in the base case, from $278 today (1.3x over 4 years). The downside path ends near $126. These are outcomes of a Monte Carlo simulation run on ILMN's historical return distribution, not price targets, and they assume no dividends are reinvested.
| Year | Downside (10th pct) | Base case | Upside (90th pct) |
|---|---|---|---|
| 2027 | $175 | $299 | $511 |
| 2028 | $150 | $321 | $684 |
| 2029 | $136 | $344 | $871 |
| 2030 | $126 | $369 | $1,080 |
| 2031 | $119 | $396 | $1,315 |
| 2032 | $114 | $426 | $1,583 |
| 2033 | $111 | $457 | $1,888 |
| 2034 | $108 | $490 | $2,235 |
| 2035 | $105 | $526 | $2,630 |
| 2036 | $104 | $565 | $3,080 |
Method: 10,000 simulated price paths using ILMN's historical volatility and drift, re-run daily. The base case is the median path; the two outer columns are the 10th and 90th percentile outcomes, which widen with time because uncertainty compounds. Simulations are not guarantees, and past volatility does not predict future returns. This is analysis, not investment advice.
People Also Watch
ILMN Insider Trading Analysis
Bought
$1.6M
4 Transactions
Sold
$592.9M
18 Transactions
Insiders
23
Active Traders
Avg Transaction
$27.0M
Large trades
| Date | Insider | Type | Shares | Value |
|---|---|---|---|---|
| Aug 5, 2026 | MEISTER KEITH A
Director
|
Sell | 741.1K | $148.2M |
| Aug 21, 2026 | MEISTER KEITH A
Director
|
Sell | 679.6K | $145.6M |
| Jun 1, 2026 | MEISTER KEITH A
Director
|
Sell | 669.6K | $107.0M |
| Aug 27, 2026 | MEISTER KEITH A
Director
|
Sell | 375.9K | $85.2M |
| Sep 4, 2026 | MEISTER KEITH A
Director
|
Sell | 263.6K | $57.2M |
| May 14, 2026 | MEISTER KEITH A
Director
|
Sell | 329.5K | $47.9M |
| Feb 16, 2021 | FLATLEY JAY T
Director
|
Sell | 4.5K | $2.3M |
| Feb 2, 2021 | FLATLEY JAY T
Director
|
Sell | 4.0K | $1.8M |
| Mar 2, 2021 | FLATLEY JAY T
Director
|
Sell | 4.0K | $1.8M |
| Aug 31, 2020 | RAGUSA ROBERT P
Officer
|
Sell | 5.0K | $1.8M |
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Frequently Asked Questions
Is Illumina Inc. stock a buy right now?
Illumina Inc. is currently rated a 'Hold' by Wall Street analysts, with a median price target of $214.00, suggesting a potential downside from its current price of $278.17. Significant insider selling and a recent earnings miss add to the caution, despite positive technical momentum.
What is Illumina Inc.'s price target for the next 12 months?
The median analyst price target for Illumina Inc. is $214.00, indicating a -23.1% downside from the current trading price. This target is based on the consensus of 21 analysts covering the stock.
How has Illumina Inc. performed in its recent earnings reports?
Illumina Inc. reported a significant earnings miss for the quarter ending June 2026, with actual EPS of -$0.02 against an estimate of $0.04. This follows a strong beat in the prior quarter, highlighting an inconsistent earnings trend.
What are the main risks facing Illumina Inc.?
The primary risks for Illumina Inc. include substantial insider selling, a premium valuation compared to sector peers, and a negative outlook from Wall Street analysts. The recent earnings miss also introduces uncertainty regarding operational performance.
What is Illumina Inc.'s revenue growth outlook?
Illumina Inc. is projected to achieve 6.00% revenue growth for the current year, with next year's growth also estimated at 6.00%. The next quarter's revenue growth is anticipated to be around 5.00%.
How does Illumina Inc.'s valuation compare to its sector peers?
Illumina Inc. trades at a P/E ratio of 50.60 and a price-to-sales ratio of 9.11, both significantly higher than the Healthcare sector medians of 31.9 and 3.7, respectively. This indicates a premium valuation for Illumina.
What is the long-term projection for Illumina Inc. stock?
Based on Monte Carlo simulations, Illumina Inc.'s stock price projection for 2030 shows a base case of $369.31, a downside case of $126.34, and an upside case of $1079.57. These are statistical outcomes, not guarantees.