Head-to-head · Stock vs Stock
Vertex Pharmaceuticals Incorporated vs Regeneron Pharmaceuticals
Stock·NASDAQ
Vertex Pharmaceuticals Incorporated VRTX
$547.85
▼ 0.55%
69 / 100 AI score
vs
Stock·NASDAQ
Regeneron Pharmaceuticals, Inc. REGN
$916.06
▼ 0.42%
87 / 100 AI score
VRTX vs REGN: the verdict
How VRTX and REGN compare today, and what CleaRank Financial AI makes of it.
The verdict
CleaRank Financial AI favours
REGN
VRTX
REGN
69/100
AI score
87/100
+30.1%
1-year change
+39.9%
36.8%
Volatility (30d, yearly)
54.4%
57.8
RSI (14-day)
64.3
35.3x
P/E ratio
20.3x
No dividend
Dividend yield
0.40%
The verdict
Regeneron Pharmaceuticals (REGN) comes out ahead on CleaRank's model, scoring 87/100 (Strong Buy) against 69/100 (Buy) for Vertex Pharmaceuticals Incorporated (VRTX). The widest gap is the earnings record: for REGN, it beat estimates in 6 of the 7 reports in our data and the latest report beat the estimate by 23.51%. For VRTX, it beat estimates in 3 of the 7 reports in our data and the latest report missed the estimate by 0.42%.
Key difference
Valuation also favours REGN: the P/E of 20.25 is 36.5% below the sector median (a discount to peers). For VRTX, the P/S of 10.78 is 217.1% above the sector median.
Outlook
VRTX's uptrend holds while it stays above its 50-day average at $523.05 and its 200-day at $482.34. REGN's uptrend holds while it stays above its 50-day average at $809.24 and its 200-day at $743.93.
Price, side by side
Both prices start at 0% on the first day of the period you pick, so the moves compare directly.
Rebased price
0%+10%+20%+30%+23%+7.4%
Nov '26
-10%0%+10%+20%+15%+3.4%
Sep '26Oct '26Nov '26
-20%-10%0%+10%+20%+30%+27%+22%
Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
0%+20%+40%+40%+30%
Dec '25Feb '26Apr '26Jul '26Sep '26Nov '26
-60%-40%-20%0%+20%+15%-22%
Oct '24Mar '25Aug '25Jan '26Jun '26Nov '26
Over 1 year: VRTX gained 30.1% and REGN gained 39.9%, a gap of 9.8 points in REGN's favour.
Valuation and profitability
What each costs relative to its earnings and sales, and how much of its revenue it keeps.
Side by side
Valuation
Lower multiples mean you pay less for each dollar of earnings or sales.
VRTX
REGN
$138.9B
Market cap
$94.8B
35.3x
P/E ratio
20.3x
10.8x
Price / sales
5.6x
6.7x
Price / book
2.7x
27.4x
EV / EBITDA
15.2x
Profitability
How much of each dollar of revenue becomes profit, and how hard the capital works.
VRTX
REGN
+12.5%
Revenue growth (quarter, y/y)
+16.7%
30.7%
Net margin
28.5%
20.8%
Return on equity
14.9%
10.6%
Return on assets
7.6%
0.31
Debt / equity
0.08
On valuation
VRTX carries the higher trailing P/E, at 35.25 against 20.25 for REGN. The sector median P/E is 31.9. VRTX's P/E is broadly in line with peers, while REGN's sits at a discount to peers. VRTX is also valued higher on sales, at 10.78 times against 5.56. In size, VRTX is the larger company, with a market capitalisation of $138.9B against $94.8B.
On profitability
VRTX turns more of its sales into profit, with a net margin of 30.70% compared with 28.51% for REGN. Its return on equity is also higher, at 20.80% against 14.95%. Looking at the latest quarter against the same quarter a year earlier, revenue grew 12.45% at VRTX and 16.73% at REGN. Our data reports no dividend for VRTX, while REGN carries a trailing dividend yield of 0.40%.
Earnings reality check
VRTX
VRTX beat the estimate in 3 of its last 7 reports (latest Nov '26); the shares fell in the first session after 3 of those beats.
Surprise
Next session
May '25Nov '25May '26Nov '26
REGN
REGN beat the estimate in 6 of its last 7 reports (latest Oct '26); the shares fell in the first session after 1 of those beats.
Surprise
Next session
Feb '25Aug '25Apr '26Oct '26
Momentum and sentiment
The indicators behind each AI score, side by side.
Indicators side by side
VRTX
REGN
69/100
AI score
87/100
57.8
RSI (14-day)
64.3
+4.7%
Price against 50-day average
+13.2%
+13.6%
Price against 200-day average
+23.1%
Technicals
VRTX is in an uptrend, trading 4.74% above its 50-day average and 13.58% above its 200-day average. Its 14-day RSI is 57.8, in the neutral zone, with the MACD line positive. REGN is in an uptrend, trading 13.20% above its 50-day average and 23.14% above its 200-day average. Its 14-day RSI is 64.3, in the bullish zone, with the MACD line positive. VRTX sits higher in its 52-week range, at 87% against 81% for REGN.
Sentiment
Of the 32 analysts covering VRTX, 26 rate it buy, 4 hold and 2 sell; their median target is $578.00, 5.5% above the price. Of the 28 analysts covering REGN, 19 rate it buy, 9 hold and 0 sell; their median target is $982.00, 7.2% above the price.
Risk and practical tips
How much each moves, how much return each has paid for that risk, and what to watch if you hold either.
Risk measures
VRTX
REGN
36.8%
Volatility (30d, yearly)
54.4%
0.28
Beta against the S&P 500
0.10
0.23
Sharpe ratio
-0.24
Risk
REGN typically moves more in a day, 3.04% against 2.01% for VRTX. Against the S&P 500, VRTX has a beta of 0.28 and REGN 0.10. Their worst falls in the price history were 39.1% for VRTX (July 2020 to October 2021) and 59.0% for REGN (August 2024 to June 2025). The measures split: VRTX has the higher beta, while REGN typically moves more in a day and has had the deeper worst fall.
ProTips
- For VRTX, watch the 52-week high at $568.67 above the price and the 20-day EMA at $534.31 below it.
- For REGN, watch the 52-week high at $991.73 above the price and the 20-day EMA at $866.52 below it.
VRTX vs REGN: long-term scenarios
Simulated paths from each price history. A range of outcomes, not a forecast.
Simulated growth of $10,000
$20K$40K$60K$80K$82.8K$63.4K$23.8K$18.5K
202620282030203220342035
VRTX
REGN
$6,836
Downside, 2035 (10th)
$5,373
$23,784
Base case, 2035 (median)
$18,462
$82,758
Upside, 2035 (90th)
$63,432
In the median simulated path, $10,000 in VRTX grows to about $23,800 and $10,000 in REGN grows to about $18,500 by 2035. The paths come from each asset's own volatility and capped historical trend; they are statistical outcomes, not forecasts. VRTX and REGN's upside columns reach an extreme multiple of the starting amount; treat them as a statistical tail, not a likely outcome.
VRTX vs REGN: questions people ask
Answered from the figures on this page.
Frequently Asked Questions
Which is better, VRTX or REGN?+
On CleaRank's model REGN scores higher, 87/100 (Strong Buy) against 69/100 (Buy) for VRTX. This describes the data on this page and is not a personal recommendation.
Which has performed better over the past year, VRTX or REGN?+
Over the past year REGN has done better. Its price rose 39.91%, while VRTX rose 30.07%.
Which is cheaper on earnings, VRTX or REGN?+
REGN carries the lower trailing P/E, at 20.25 against 35.25 for VRTX.
Which pays more income, VRTX or REGN?+
REGN has the higher yield, 0.40%, while no yield is reported for VRTX. A yield is the payout divided by the price, so it changes when either one does.
Which is riskier, VRTX or REGN?+
Most of the measures we track point to REGN as the riskier of the two. Average daily move: 2.01% for VRTX, 3.04% for REGN. Beta against the S&P 500: 0.28 for VRTX, 0.10 for REGN. Worst fall in the price history: 39.1% for VRTX, 59.0% for REGN.
Which has stronger momentum right now, VRTX or REGN?+
REGN has the higher 14-day RSI, 64.3 (bullish) against 57.8 (neutral) for VRTX. Both MACD lines are positive. Readings above 70 or below 30 mark stretched momentum.
Which is the bigger company, VRTX or REGN?+
VRTX is the larger company, with a market value of $138.9B against $94.8B for REGN.
What do analysts say about VRTX and REGN?+
VRTX has 26 buy ratings out of 32, and its median target is 5.5% above the price. REGN has 19 buy ratings out of 28, and its median target is 7.2% above the price.
How would $10,000 have grown in VRTX or REGN?+
Invested in December 2016, $10,000 would be worth $70,788 today in VRTX and $24,622 in REGN.